“Top Gun” takes in $1.9 million in 3D Imax re-release






LOS ANGELES (TheWrap.com) – There’s apparently still some thrust in the box-office afterburners for “Top Gun,” which took in $ 1.9 million from 300 Imax theaters over the weekend in a 3D re-release by Paramount.


The studio slotted its 1986 classic in a six-day run that began Friday with Imax to help publicize the film’s 3D Blu-ray release on February 19, so the box office is a bonus. It averaged roughly $ 6,600 per screen.






It was re-mastered for the big screen from high-resolution original negative scans and painstakingly converted to 3D by Legend3D under the supervision of the film’s director, Tony Scott.


The story of an elite group of pilots competing to be the best in their class earned a worldwide box office of more than $ 350 million in its initial release. The film stars Tom Cruise as Maverick and Kelly McGillis as his civilian instructor. Val Kilmer, Anthony Edwards and Meg Ryan co-star.


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FDA rebuff deals big blow to Novo Nordisk’s U.S. hopes






COPENHAGEN (Reuters) – U.S. regulators dealt a major blow to Novo Nordisk‘s hopes for its new long-acting insulin Tresiba by demanding the Danish drugmaker conduct additional clinical tests to assess potential heart risks.


Novo, the world’s biggest insulin maker, said the U.S. Food and Drug Administration (FDA) had requested additional data from a dedicated cardiovascular outcomes trial before it would consider approving Tresiba and related product Ryzodeg.






The drugmaker – which is banking on Tresiba to keep it in the lead in diabetes care – said on Sunday it did not expect to be able to provide the data during 2013. Analysts said the FDA’s stance could delay Tresiba until 2015 or 2016.


“They will have to make new studies and that will delay the launch of Tresiba in the U.S. by two to three years,” Sydbank analyst Soren Hansen said.


“It is a really bad situation … I expect the share will fall significantly on Monday.”


The setback for Tresiba, also known as degludec, is good news for rival makers of insulin medicines, including France’s Sanofi, whose Lantus product is under threat from Novo’s newer ultra-long-lasting treatment.


Most investors had expected a green light from the U.S. watchdog, following a positive recommendation from an advisory panel to the FDA last November.


Optimism about Tresiba and Ryzodeg – which combines degludec with another formulation of insulin – was further boosted by approval in Europe, where the drugs won a final go-ahead last month. They have also been approved in Japan.


Tresiba and Ryzodeg have been widely tipped by analysts to become multibillion-dollar-a-year sellers worldwide.


CONFOUNDS EXPECTATIONS


The FDA’s decision to issue Novo with a so-called “complete response letter” therefore confounded consensus expectations. Such letters are issued when the U.S. agency determines that an application cannot be approved in its existing form.


“We are surprised and disappointed to receive this letter, but we acknowledge this decision by the FDA and will work with the agency to determine the best path forward to completing the review,” Novo Chief Executive Lars Rebien Sorensen said in a statement.


Concerns about the cardiovascular safety of Tresiba are not new, but Novo and most analysts had thought the issue had been resolved.


The FDA advisers meeting last year expressed concern about a trend toward higher incidence of adverse heart events with the new insulin than with older ones. However, the differences seen in 16 large clinical trials were not statistically significant.


In addition to calling for new trials on Tresiba’s heart safety, the FDA said approval for Tresiba and Ryzodeg could not be granted until violations cited in a December 12 warning letter had been resolved.


Novo said the FDA’s decision not to grant approval at the present time was not expected to impact significantly its financial forecasts for the current year.


The big concern of investors, though, is that a lengthy delay in getting Tresiba launched in the world’s biggest drugs market will seriously undermine Novo’s ability to stay ahead of rivals such as Sanofi and Eli Lilly.


(Additional reporting by Ole Mikkelsen and Ben Hirschler; Editing by Maureen Bavdek and Dale Hudson)


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Israel’s Lieberman says Palestinian peace accord impossible






JERUSALEM (Reuters) – Israel has no chance of signing a permanent peace accord with the Palestinians and should instead seek a long-term interim deal, the most powerful political partner of Prime Minister Benjamin Netanyahu said on Saturday.


The remarks by Avigdor Lieberman, an ultranationalist whose joint party list with Netanyahu narrowly won a January 22 election while centrist challengers made surprise gains, seemed designed to dampen expectations at home and abroad of fresh peacemaking.






A spring visit to Israel and the Palestinian territories by U.S. President Barack Obama, announced this week, has stirred speculation that foreign pressure for a diplomatic breakthrough could build – though Washington played down that possibility.


In a television interview, ex-foreign minister Lieberman linked the more than two-year-old impasse to pan-Arab political upheaval that has boosted Islamists hostile to the Jewish state.


These include Hamas, rivals of U.S.-backed Palestinian President Mahmoud Abbas, who control the Gaza Strip and spurn coexistence with Israel though they have mooted extended truces.


“Anyone who thinks that in the center of this socio-diplomatic ocean, this tsunami which is jarring the Arab world, it is possible to arrive at the magic solution of a comprehensive peace with the Palestinians does not understand,” Lieberman told Israel’s Channel Two.


“This is impossible. It is not possible to solve the conflict here. The conflict can be managed and it is important to manage the conflict … to negotiate on a long-term interim agreement.”


Abbas broke off talks in late 2010 in protest at Israel’s settlement of the occupied West Bank. He angered Israel and the United States in November by securing a U.N. status upgrade that implicitly recognized Palestinian independence in all the West Bank, East Jerusalem and Gaza.


Israel insists it will keep East Jerusalem and swathes of West Bank settlements under any eventual peace deal. Most world powers consider the settlements illegal because they take up land seized in the 1967 Middle East war.


Lieberman, himself a West Bank settler, said the ball was “in Abu Mazen’s (Abbas’) court” to revive diplomacy.


Abbas has demanded Israel first freeze all settlement construction. With two decades gone since Palestinians signed their first interim deal with Israel, he has ruled out any new negotiations that do not solemnize Palestinian statehood.


Netanyahu’s spokesman Mark Regev noted that Lieberman, in the Channel Two interview, had said he was expressing his own opinion.


Asked how Netanyahu saw peace prospects for an accord with the Palestinians, Regev referred to a speech on Tuesday in which the conservative prime minister said that Israel, while addressing threats by its enemies, “must also pursue secure, stable and realistic peace with our neighbors”.


Netanyahu has previously spoken in favor of a Palestinian state, though he has been cagey on its borders and whether he would be prepared to dismantle Israeli settlements.


Lieberman’s role in the next coalition government is unclear as he faces trial for corruption. If convicted, he could be barred from the cabinet. Lieberman denies wrongdoing and has said he would like to regain the foreign portfolio, which he surrendered after his indictment was announced last year.


(Writing by Dan Williams; Editing by Stephen Powell)


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Beyonce, Jay-Z, Rihanna hang at Roc Nation brunch






LOS ANGELES (AP) — Jay-Z and Beyonce sat tightly with Solange. Kelly Rowland embraced Beyonce with a huge hug. And Rihanna spilled some of her drink laughing with Rowland.


Music’s top stars attended the annual pre-Grammy Roc Nation brunch Saturday at the Soho House.






Grammy nominee Miguel, Timbaland, Jill Scott and Kylie Mingoue also attended the exclusive event.


Jay-Z is one of six acts nominated for six awards at Sunday’s Grammys. Rihanna is up for three trophies, and Beyonce is nominated for one award.


The crowd Saturday was full of members of music industry, who mingled with performers like The-Dream, Jordin Sparks, Melanie Fiona, Diane Warren, Christina Milian, MC Lyte and Santigold.


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Egypt PM in hot water over “unclean breasts” remarks






CAIRO (Reuters) – Egypt‘s prime minister faces accusations of being out of touch with the country’s crisis after televised comments blaming rural infant sickness on mothers not washing their breasts.


Hisham Kandil, a former irrigation minister widely seen as a stolid technocrat, was speaking at a meeting with journalists broadcast on state television this week when he veered into a ramble on the “miseries” of life in rural Egypt.






“In my work, I’ve gone around the countryside,” he said. “There are villages in Egypt, in the 21st century, where children get diarrhoea … because the mothers who nurse them, out of ignorance, do not maintain personal cleanliness of their breasts.”


Recalling a visit to the Beni Suef area south of Cairo in 2004, he spoke of the dire conditions of village life. “There’s no water, there’s no sewerage,” he said. “The men go to the mosque … the women go down to the fields and get raped.”


He appeared to be responding to complaints about a series of attacks and rapes of political activists in Cairo in recent weeks, citing the case of a man who was caught on video being beaten and dragged naked by police.


“I don’t know Hamada (Saber), well, I know him like you do, but I am 99 percent sure he doesn’t pay his electricity bill,” the prime minister said of the victim of that videoed beating.


His remarks unleashed a storm of criticism, much of it reflecting a sense of economic and political malaise that has settled over the country since an uprising two years ago that toppled veteran autocratic President Hosni Mubarak.


Dina Abdel Fattah, a talk show host on the independent Tahrir channel questioned why the head of government had dwelt on the subject when Egypt was in a state of “darkness”.


At least 59 people died in 10 days of protests that started late last month over what demonstrators see as Islamist President Mohamed Mursi‘s attempts to monopolise power as well as broader economic and political grievances.


“Imagine. Our prime minister is talking about this today, when we have martyrs in the street, we have people getting killed every day, when we have entire provinces in a state of unrest,” Abdel Fattah said on her show.


Another television channel, Al Nahar, interviewed residents of Beni Suef voicing dismay at Kandil’s comments.


“It’s no good the prime minister talking this nonsense about women, good people, clean people, and ignoring all the other problems of the world,” one man said on the programme.


Since his election in June, Mursi, a member of the Muslim Brotherhood, has struggled to restore security and revive the ailing economy.


Small demonstrations continued on Friday, drawing thousands of protesters in Cairo and other cities including Tanta in the Nile Delta and Port Said on the Suez Canal.


Critics questioned Mursi’s appointment of Kandil in July, saying it was unclear whether he had the political or economic experience for the job.


“Instead of making offensive comments about poor village women and laying blame on them when God knows they are already suffering, he should be blaming himself for the failure of his government to find a proper solution to alleviate poverty, illiteracy and awful health schemes in villages,” said Iman Mahmoud, a 61-year-old housewife in Cairo.


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Spain’s “bad bank” rebuffs three investment funds






MADRID (Reuters) – Spain‘s so-called ‘bad bank’, Sareb, has rejected overtures from investment funds Cerebrus, Fortress and Centerbridge to enter into its capital because they were asking for advantages over other shareholders, a source with knowledge of the matter said on Saturday.


“They asked for privileges when it came to buying the assets, and Sareb rejected that offer,” the source, who spoke on condition of anonymity said. “Sareb has a commitment to treat all shareholders the same.”






Sareb declined to comment. None of the three funds could be reached for comment and neither the Bank of Spain nor the Economy Minister could confirm the matter.


Spain set up the bad bank to hive off rotten real estate assets dating from a property crash from lenders’ balance sheets as a condition of receiving around 40 billion euros ($ 54 billion) of European money to bail out ailing banks.


The head of Sareb, Belen Romana, sent a letter to the three funds on Friday declining their entry into the bad bank’s capital, but leaving the door open for further talks, Expansion newspaper reported on Saturday.


The funds wanted first choice on buying portfolios of finished buildings and on supplying services to the bad bank, the paper said.


Sareb took on 37 billion euros worth of troubled real estate assets at the end of December from four nationalized banks, including Bankia


(Reporting By Sonya Dowsett; Editing by Toby Chopra)


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Protests turn to street clashes across Egypt






CAIRO (AP) — Egyptian security forces backed by water cannons fired tear gas at rock-throwing protesters outside the presidential palace in Cairo on Friday while demonstrators clashed with riot police in cities across the country in marches against Islamist President Mohammed Morsi.


The protests are part of a wave of opposition-led demonstrations over the past two weeks that have frequently devolved into street clashes. The violence has left more than 70 people dead and hundreds wounded, and plunged the country into a fresh cycle of bloodshed and political turmoil.






Egypt‘s opposition is demanding Morsi form a new coalition government, open an investigation into the killings of protesters over the past months and give guarantees that upcoming parliamentary elections will be fair and free. They also want him to form a commission to amend the country’s newly adopted constitution, which was drafted by an Islamist-led panel and approved last December in a contentious referendum.


Some of the protesters go even further, demanding Morsi be removed from office. They also accuse the Muslim Brotherhood, the fundamentalist group from which Morsi hails, of monopolizing power and failing to deal with the country’s mounting woes.


Thousands took their demands to the streets in cities across the country on Friday, carrying Egyptian flags and pictures of slain protesters and chanting “down with the rule of the Guide,” referring to Brotherhood Supreme Guide Mohammed Badie, who critics allege is calling the shots for Morsi from behind the scenes.


At the presidential palace in Cairo, the scene of repeated violent clashes since late last year, protesters tried to remove the barbed wire at the front gate of the palace and fired flares at its perimeters. Riot police swiftly responded with water cannons and tear gas while protesters hurled stones.


Violence also broke out in Kafr el-Sheik, some 180 kilometers (110 miles) north of Cairo, where riot police clashed with protesters in front of the office of governor Saad el-Husseini, who is a member of the Muslim Brotherhood.


In the Mediterranean port city of Alexandria, protesters tore down a Brotherhood sign and burned it in front of the group’s office while security forces used tear gas to disperse demonstrators in front of the governor’s office.


Morsi and his allies accuse the opposition of trying to incite street violence to seize power after failing at the ballot box.


In a statement on Friday, Murad Ali, a spokesman for the Freedom and Justice party — the Muslim Brotherhood’s political arm — warned the opposition that it would be responsible for any acts of violence that occur during protests. He also called them “losers.”


The clashes over the past two weeks have fueled a sense that Egypt is coming unglued, while also raising concerns that the country could be hit by more — and greater — political violence.


Those worries sharpened after the assassination of a prominent anti-Islamist opposition leader in Tunisia on Wednesday, a killing that touched off a new wave of unrest there.


Tunisia was the birthplace of the region’s so-called Arab Spring uprisings in 2011 that brought an end to the rule of several autocrats including Egypt’s own Hosni Mubarak, clearing the way for Morsi’s election last summer. Egyptians have warily watched the events unfolding in Tunis, which many here look to as a bellwether for their own country.


Much of the public anxiety in Egypt following the killing in Tunis stems from religious edicts, known as fatwas, recently issued by extremist clerics calling for the killing of Morsi’s political opponents.


Egypt’s leading democracy advocate and opposition leader Mohamed ElBaradei sounded the alarm this week about the edicts.


The opposition says it will continue protests despite the fatwas, which the presidency and the government condemned as “terrorism.” Morsi called the rhetoric “hate speech cloaked by religion.”


Hamdeen Sabahi, a leader of the opposition National Salvation Front, said in a message posted on his Twitter account: “We will continue our peaceful struggle with the Egyptian people and revolutionary youth to continue our revolution.”


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Britney Spears considers long-term Las Vegas deal






LOS ANGELES (Reuters) – Pop star and former “X Factor” judge Britney Spears is in talks to sign a long-term contract to headline a show at a Las Vegas resort, Caesars Entertainment Corp. said on Friday.


“We can now confirm the company is actively engaged in discussions with Britney Spears‘ representatives regarding a potential headlining residency at Planet Hollywood Resort and Casino,” the company said in a statement.






Representatives for Spears were not immediately available for comment on Friday.


Caesars Entertainment, which owns casinos and resorts including Planet Hollywood, has hired some of the world’s top-selling artists for residencies at various Las Vegas sites.


Canadian singer Celine Dion has a three-year deal with Caesars Palace that is said to be worth $ 100 million. British singer Elton John also has a long-term commitment to perform at The Colosseum at Caesars Palace.


Singers Cher and Bette Midler had similar long-term deals at The Colosseum in recent years.


Spears, 31, shot to fame in the late 1990s with hits such as “… Baby One More Time” and has gone on to become one of the biggest pop figures of the 2000s.


She is waging a comeback after a turbulent few years in her life in which she lost custody of her children, entered rehab and shaved off her hair.


She landed a seat on “The X Factor” judging panel in May 2012, but left the show last month after one season. In the same week, she also split up with her fiancĂ© Jason Trawick.


(Reporting By Piya Sinha-Roy and Eric Kelsey; Editing by Xavier Briand)


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Even Healthy Older Adults Hit Hard by Flu






Cold weather and seasonal flu go hand in hand, and while we have the groundhog to provide insight into the length of winter, no one can say for certain when the 2012-13 influenza season will taper off. In its most recent Flu View report, representing data obtained from Jan. 27 through Feb. 2, the U.S. Centers for Disease Control and Prevention explains that although flu activity remained high throughout the nation, most areas reported a decrease in new cases of the illness.


Older Adults Age 65 and Over Hit Hardest by 2012-13 Influenza Season






In reviewing the laboratory-confirmed influenza hospitalizations graph provided by the CDC, the number of hospitalizations for those age 65 and older are three times that of the next highest age group. Dr. Lyn Finelli, a flu expert at the CDC, explained to NBCNews.com that this flu season’s rate of hospitalization for older adults is the highest it’s been since the agency began gathering such data in 2005.


Speaking to the number of deaths among people age 65 and over as a result of influenza and/or pneumonia, Finelli stated , “The deaths are way over the epidemic threshold,” and voiced the agency’s concern about these older members of the population in regard to influenza and its potential complications.


Finelli explained that even older adults who consider themselves generally fit and healthy have the potential to develop life-threatening complications from influenza due to underlying conditions.


CDC Recommendations to Prevent, Treat Influenza in those Age 65 and Older


The CDC continues to recommend that anyone age 6 months and older receive the flu vaccination. This is particularly important for baby boomers and seniors age 65 and older due to the increased risk of complications from influenza in this age group.


There are two vaccines available to those 65 years-of-age and older; the regular dose vaccination and a high-dose vaccination. The CDC does not prefer one of these types over the other. In theory, the high-dose vaccine is intended to provide a stronger immune response, but whether that occurs in reality is dependent on many factors. Talk with your health care provider to learn which vaccine he recommends.


If you suspect you have the flu — sudden onset of symptoms, cough, sore throat, fever or feverish with chills, tiredness, runny or stuffy nose, muscle/body aches — contact your health care provider immediately. You need not have all of the symptoms, and may not have a fever and still be ill with the flu.


There are two anti-viral medications your health care provider can prescribe, but they work best when taken within 48 hours of the symptoms first appearing. These anti-viral medications are intended to reduce the severity of the illness and potentially to prevent complications of influenza.


Research Finds that Older Adults Have Different and Fewer Antibodies Than Younger People


The peer-reviewed medical journal Science Translational Medicine published the results of research into the understanding of the antibody responses in older adults. The antibody response is the body’s method of fighting infection and also the portion of the system that develops a protective response following vaccination. Not only do older adults have fewer antibodies than their younger cohorts, but they have different types of antibodies. The number and types of antibodies decreases with age.


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Firms face horsemeat ‘disaster’












The latest scandal surrounding horsemeat in processed food could be “disastrous” for the meat processing industry, retail analysts are warning.


Lost contracts with supermarkets “will undoubtedly cost them millions of pounds”, Neil Saunders of retail analyst Conlumino told the BBC.


“The loss of supply contracts could be disastrous for food suppliers.”


The Food Standards Agency now wants the industry to test all its processed beef products.


The British Meat Processors Association, whose members produce 80% of meat sold in the UK, said: “It’s too early to say what the impact will be on our industry. The BMPA is co-operating with the FSA [Food Standards Agency] to establish the facts, and to deal effectively with the issues.”


One supplier, meat processor Silvercrest, based in County Monaghan, Ireland, lost supply contracts with Tesco, Aldi and Co-operative supermarkets after the Food Safety Authority of Ireland (FSAI) found horse and pig DNA in burgers it supplied.


“It wouldn’t surprise me if there were redundancies,” said Mr Saunders.


A spokesperson for ABP Food Group, which owns Silvercrest, said: “We feel it would be inappropriate to comment at this stage.”


Testing regime


In a statement issued on Friday, the FSA said: “In addition to the widespread testing we are doing, we’ve instructed the industry to urgently carry out its own tests on processed beef products to see whether horsemeat is present.”


But this new testing regime could cost the industry millions of pounds.


Giving evidence to the Environment, Food & Rural Affairs select committee on 30 January, Tim Smith, Tesco’s group technical director revealed that the supermarket’s new DNA testing regime, introduced following the discovery of horsemeat in its value burgers, would cost it “£1m to £2m a year”.


Meanwhile, Tesco’s sales loss would be “a lot bigger than a million pounds” as a result of the scandal, he said.


But Richard Dodd of the British Retail Consortium, which represents 80% of the UK retail industry, told the BBC: “What we’re hearing from our members is that this [horsemeat] issue is not having an impact. People are clear that it isn’t a health issue, so it’s not producing a change in customer shopping habits.”


And Conlumino’s Neil Saunders agrees that the supermarkets are unlikely to be affected much by the scandal, since they can claim compensation from their suppliers.


“While it is highly likely that sales will have deteriorated in some food lines, such as value burgers, other categories may have benefitted, meaning that there is little net loss overall,” he said.


Traditional High Street butchers might even be benefiting from the horsemeat scandal, says Richard Stevenson, technical manager of the National Federation of Meat and Food Traders.


“Our members are telling us that they’re all getting more business since the Tesco burger issue, because most butchers know exactly where their meat has come from. You could argue that this issue has arisen as a direct result of the cheap food policy adopted by supermarkets.”


Findus, which had to withdraw its beef lasagne ready meals after some samples were found to contain 100% horsemeat, said on Friday that it had tested all its other beef products and found no evidence of contamination.


BBC News – Business





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